Serum neurofilament light chain measurement can help identify individuals with radiologically isolated syndrome who are at high risk for multiple sclerosis conversion.
Self-reported language impairment in MS can be predicted by self-reported cognitive impairment, speech and voice impairment, yes/no response to a binary question on presence of language impairment, group membership and participation, and negative effect on quality of life.
A novel battery of self-administered, smartphone application–based neuroperformance tests would allow more frequent, remote assessments of motor and cognitive function in people with multiple sclerosis.
More data are needed to ascertain the actual risks and benefits of DMT use, discontinuation, and de-escalation in older people with MS.