Abstracts from the Fifth Conference of the International Multiple Sclerosis Cognition Society

Platforms

(1) BICAMS in Daily Clinical Practice: Results of the German BICAMS Feasibility Study

M Filser¹, C Lassek², IK Penner^1,3

¹COGITO Center for Applied Neurocognition and Neuropsychological Research, Düsseldorf, Germany; ²Neurological Group Practice, Kassel/Vellmar, Germany; ³Department of Neurology, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany

(2) Cognitive Profiles of Patients with Clinically Isolated Syndrome and Early Relapsing-Remitting Multiple Sclerosis

VS Chavarro¹, E Freitag¹, C Chien¹, M Scheel¹, J Behrens¹, K Ruprecht², J Bellmann-Strobl^1,3, AU Brandt^1*, P Friedemann^1,2,3*

¹NeuroCure Clinical Research Center, Charité-Universitätsmedizin Berlin, Berlin, Germany; ²Department of Neurology, Charité-Universitätsmedizin Berlin, Berlin, Germany; ³Experimental and Clinical Research Center, Charité-Universitätsmedizin Berlin, Berlin, and Max Delbrück Center for Molecular Medicine, Berlin-Buch, Germany; ^*These authors contributed equally.

(3) Long-Term Prognosis in Multiple Sclerosis—A 25-Year Follow-Up

EG Celius¹, H Sletvold², NI Landrø³

¹Department of Neurology, Oslo University Hospital Ullevål, Oslo, Norway; ²Olav Trygvasons gate 24, 7011 Trondheim, Norway; ³Institute of Psychology, University of Oslo, Oslo, Norway

(4) Hippocampal Microstructural Damage and Memory Impairment in Multiple Sclerosis: A Translational Study from Animal Model to Clinically Isolated Syndrome and Multiple Sclerosis Patients

B Brochet^*, V Planche, A Ruet, P Coupé, D Hamel, M Deloire, F Munsch, A Saubusse, J Charré-Morin, V Dousset, T Tourdias^*

Bordeaux Hospital Centre and University of Bordeaux, INSERM U 1215, Bordeaux, France; ^*These authors jointly directed this work.

(5) Default-Mode and Frontoparietal Network Dysfunction in Cognitively Impaired Multiple Sclerosis Patients

KA Meijer¹, AJC Eijlers¹, BMJ Uitdehaag², F Barkhof³, JJG Geurts¹, MM Schoonheim¹

¹Department of Anatomy and Neurosciences, VU University Medical Center, Amsterdam, the Netherlands; ²Department of Neurology, VU University Medical Center, Amsterdam, the Netherlands; ³Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, the Netherlands

(6) Systematically Developed Pilot Randomized Controlled Trial of Exercise and Cognition in Persons with Multiple Sclerosis

BM Sandroff¹, JM Balto², RE Klaren², SK Sommer², J DeLuca¹, RW Motl²

¹Kessler Foundation, West Orange, NJ, USA; ²Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Urbana, IL, USA

(7) Focal Gray Matter Preservation Is Associated with Improved PASAT Scores in Multiple Sclerosis Patients Treated with Estriol

F Kurth¹, HJ Wang², R Voskuhl¹, A MacKenzie-Graham¹

¹Department of Neurology, UCLA School of Medicine, Los Angeles, CA, USA; ²Department of Biomathematics, UCLA School of Medicine, Los Angeles, CA, USA

(8) Age of Disease Onset and Baseline IQ Are Significant Predictors of Maturational Trajectory in Symbol Digit Modalities Test Performance in Pediatric Multiple Sclerosis

N Akbar¹, A Signori², MP Amato³, MP Sormani³, E Portaccio⁴, C Niccolai⁴, B Goretti⁴, C Till⁵, B Banwell⁶

¹Neuroscience and Neuropsychology Laboratory, Kessler Foundation, West Orange, NJ, USA; ²Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy; ³Department of Neurology, University of Florence, Florence, Italy; ⁴Department of Psychology, York University, Toronto, Ontario, Canada; ⁵Department of Neurology, Children's Hospital of Philadelphia, Philadelphia, PA, USA; ⁶Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, Ontario, Canada

(9) Social Cognition and Cognitive Impairment in Multiple Sclerosis

B Brochet, C Dulau, A Prouteau, M Deloire, H Diaz, A Saubusse, J Charré-Morin

Bordeaux Hospital Centre and University of Bordeaux, INSERM 1215, Bordeaux, France

(10) Age and Disability Drive Cognitive Impairment in Multiple Sclerosis Independent of Disease Subtype: Insights from an Italian Multicenter Study

L Ruano¹, E Portaccio², B Goretti², C Niccolai², F Patti³, S Cilia³, P Gallo⁴, P Grassi⁴, A Ghezzi⁵, M Roscio⁵, F Mattioli⁶, C Stampatori⁶, M Trojano⁷, RG Viterbo⁷, MP Amato²

¹EPIUnit–Institute of Public Health, University of Porto, Porto, Portugal; ²University of Florence, Florence, Italy; ³University of Catania, Catania, Italy; ⁴University of Padova, Padova, Italy; ⁵Gallarate Hospital, Gallarate, Italy; ⁶Spedali Civili Brescia, Brescia, Italy; ⁷University of Bari, Bari, Italy

Posters

(1) Impact of Executive Function on Language Dysfunction in Multiple Sclerosis

H Joly, M Cohen, C Lebrun

MS Clinic, Centre Hospitalier Universitaire, Pasteur 2, Nice, France

(2) Data-Driven Analysis of Cognitive Status in Primary Progressive Multiple Sclerosis: Intrinsic Functional Connectivity and Variability Across Multiple Frequency Bands

M Petracca^1,2, C Saiote¹, HA Bender³, F Arias³, C Farrell¹, P Magioncalda⁴, M Martino⁴, A Miller¹, G Northoff⁵, F Lublin¹, M Inglese^1,6,7,8

¹Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; ²Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples “Federico II,” Naples, Italy; ³Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA; ⁴Department of Neuroscience, Section of Psychiatry, IRCCS AOU San Martino-IST, University of Genoa, Genoa, Italy; ⁵Institute of Mental Health Research, University of Ottawa, Ottawa, Ontario, Canada; ⁶Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; ⁷Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA; ⁸Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, and Mother-Child Health, University of Genoa, Genoa, Italy.

(3) Thalamic Atrophy Correlates with Cognitive Dysfunction in Relapsing-Remitting Multiple Sclerosis Patients Treated with Natalizumab

JT Bernard, A Javed, G Talmage

University of Chicago, Chicago, IL, USA

(4) Detection of Leukocortical Lesions with Phase-Sensitive Inversion Recovery and Their Relation to Cognitive Deficits in Multiple Sclerosis

Y Forslin^1,2, G Bergendal¹, J Martola^1,2, F Hashim^1,2, S Shams^1,2, M Kristoffersen-Wiberg^1,2, T Granberg^1,2, S Fredrikson^3,4

¹Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden; ²Department of Radiology, Karolinska University Hospital, Stockholm, Sweden; ³Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; ⁴Department of Neurology, Karolinska University Hospital, Stockholm, Sweden

(5) Assessing Cognitive and Functional Impairments for People with Multiple Sclerosis in the Home and Community

R Carroll, M Cola

Main Line Rehabilitation Associates, Exton, PA, USA

(6) Social Cognition and Cognitive Reserve in Early Multiple Sclerosis Patients

SA de Rodez Benavent^1,2,*, GO Nygaard^2,3,*, HF Harbo^2,3, S Tønnesen², E Kerty^2,3, L Drolsum^1,2, NI Landrø⁴, EG Celius³, B Laeng⁴

¹Department of Ophthalmology, Oslo University Hospital, Oslo, Norway; ²Department of Clinical Medicine, University of Oslo, Oslo, Norway; ³Department of Neurology, Oslo University Hospital, Oslo, Norway; ⁴Department of Psychology, University of Oslo, Oslo, Norway; ^*These authors contributed equally.

(7) A Single Bout of Physical Exertion and Its Effect on Expressive Language Skills in Individuals with Multiple Sclerosis

MA Barrera^1,2, PO Goodell², HI Karpatkin^1,3

¹CUNY, Graduate Center, New York, NY, USA; ²ASPIRE CENTER for Health + Wellness, New York, NY, USA; ³CUNY, Hunter College, New York, NY, USA

(8) Indications for Symbol Digit Modalities Test in Newly Diagnosed for Cognitive Assessment for Multiple Sclerosis

KA Smith, ES Riser, TF Tracy

Tanner Center for Multiple Sclerosis, Birmingham, AL, USA

(9) MSCOG Normative Study: Analysis of Methodology and Applicability for Clinical Research

M Mellion¹, J DeLuca², RHB Benedict³, T Kaushik⁴, B Brochet⁵, U Nocentini⁶, FW Foley⁷, J Wilken⁸, G Phillips¹, Y Zhang¹, L Xu¹, D Cadavid¹

¹Biogen, Cambridge, MA, USA; ²Kessler Foundation, West Orange, NJ, and Department of Physical Medicine & Rehabilitation and of Neurology, Rutgers New Jersey Medical School, Newark, NJ, USA; ³State University of New York at Buffalo, University at Buffalo School of Medicine and School of Medicine and Biomedical Sciences, State University of New York (SUNY), Buffalo, NY, USA; ⁴Formerly of PanMedix, Inc., New York, NY, USA; ⁵Bordeaux Hospital University Centre and University of Bordeaux, Bordeaux, France; ⁶IRCCS Fondazione Santa Lucia and Università di Roma Tor Vergata, Rome, Italy; ⁷Ferkauf Graduate School of Psychology, Yeshiva University, Bronx, NY, and Holy Name Medical Center Multiple Sclerosis Center, Teaneck, NJ, USA; ⁸Department of Neurology, Georgetown University Hospital, and Washington Neuropsychology Research Group, LLC, Washington, DC, USA

(10) Cognitive-Motor Interference and Cerebellar Involvement in Patients with Multiple Sclerosis

O Argento¹, B Spanò², C Incerti¹, M Bozzali^2,3, C Caltagirone^1,3, V Pisani¹, U Nocentini^1,3

¹Neurology and Neurorehabilitation Unit, IRCCS “Santa Lucia” Foundation, Rome, Italy; ²Neuroimaging Unit, IRCCS “Santa Lucia” Foundation, Rome, Italy; ³Department of Systems Medicine, University of Rome “Tor Vergata,” Rome, Italy

(11) Low-Dose Naltrexone Maintains Stable Condition in Multiple Sclerosis Patients: A Retrospective View

M Ludwig, A Turel, P McLaughlin

Pennsylvania State University College of Medicine, Hershey, PA, USA

(12) Remediation of Emotional Processing Deficits in Multiple Sclerosis: A Pilot Study

J Lengenfelder, H Genova, D Vasquez, S Lavrador, N Chiaravalloti

Kessler Foundation, West Orange, NJ, USA

(13) Cognition Through Doing: A Cognitive Occupation-Based Program for People with Multiple Sclerosis (COB-MS)

SM Hynes¹, SJ Forwell²

¹National University of Ireland, Galway, Ireland; ²University of British Columbia, Vancouver, British Columbia, Canada

(14) The Turkish Validation of the Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) Battery

S Ozakbas¹, P Yiğit¹, H Limoncu¹, T Kahraman², BP Cinar³, G Kösehasanoğulları⁴

¹Department of Neurology, Dokuz Eylul University, Balcova, Izmir, Turkey; ²School of Physical Therapy and Rehabilitation, Dokuz Eylul University, Balcova, Izmir, Turkey; ³Education and Training Hospital, Samsun, Turkey; ⁴State Hospital, Usak, Turkey

(15) Multiple Sclerosis and Cognitive Fatigue: Relationship to Visual Evoked Potential Latency

M Gudesblatt¹, J Srinivasan¹, D Nemirov¹, K Wissemann¹, M Zarif¹, B Bumstead¹, L Fafard¹, M Buhse¹, K Blitz¹, C Sullivan², J Wilken², D Golan^3,4, GM Doniger⁵

¹South Shore Neurologic Associates, Patchogue, NY, USA; ²Neuropsychological Associates, Fairfax, VA, USA; ³Department of Neurology, Carmel Medical Center, Haifa, Israel; ⁴Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel; ⁵NeuroTrax Corp, Modiin, Israel

(16) Cognition, Patient-Reported Behavioral Outcomes, and Adherence in Multiple Sclerosis Patients on Dimethyl Fumarate—A 12-Month Observational Study in German Multiple Sclerosis Practice Centers

L Thaler¹, S Scholl¹, F Roßnagel², S Schlegel³, U Braisch³, R Muche³, M Lang^2,4, A Bergmann², H Schreiber^2,4

¹Medical Faculty, Ulm University, Ulm, Germany; ²NeuroTransData (NTD) Study Group on Multiple Sclerosis, Neuburg, Germany; ³Institute for Biomedical Statistics and Epidemiology, Ulm University, Ulm, Germany; ⁴Neuropoint Patient Academy, Ulm, Germany

(17) Increased Default-Mode Centrality in Cognitively Impaired Multiple Sclerosis Patients

AJC Eijlers¹, KA Meijer¹, TM Wassenaar¹, BMJ Uitdehaag², F Barkhof³, AM Wink³, JJG Geurts¹, MM Schoonheim¹

¹Department of Anatomy and Neurosciences, VU University Medical Center, Amsterdam, the Netherlands; ²Department of Neurology, VU University Medical Center, Amsterdam, the Netherlands; ³Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, the Netherlands.

(18) The BICAMS Applied: Examination of Repeated Administration Across Multiyear Clinical Use

LA Kostich¹, D Wakefield²

¹Mount Sinai Rehabilitation Hospital/Mandell Center, Hartford, CT, USA; ²University of Connecticut Health, Center for Public Health and Health Policy, Farmington, CT, USA

(19) Ocular Motor Cognitive Assessment: A Sensitive Measure of Progression

J Fielding^1,2, M Clough¹, O White¹

¹Department of Neurology, Royal Melbourne Hospital, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Melbourne, Victoria, Australia; ²School of Psychological Sciences and Monash Institute of Cognitive and Clinical Neurosciences, Monash University, Clayton, Victoria, Australia